Read Our Latest Whitepaper Here

Cancer remains a formidable challenge worldwide, necessitating innovative solutions and the critical need for models that precisely mimic human responses, given the high failure rates in clinical trials. This whitepaper reveals how MIMETAS's pioneering organ-on-a-chip technology and 3D tissue modeling expertise represent a significant advancement in closing the translational gap in cancer drug discovery. MIMETAS' cancer modeling capabilities are showcased through six case studies, highlighting our ability to model processes such as immune cell migration, CAR T cell efficacy, and the TME's complex interactions, all contributing to drug discovery progress.

Developing effective therapies for immunological diseases remains a major challenge due to the complexity of the immune system and limitations in traditional preclinical models. Many promising drug candidates fail in clinical trials due to a lack of predictive accuracy in existing in vitro and in vivo models. This whitepaper examines how advanced 3D tissue models can improve translational relevance in immunology drug discovery, addressing key challenges in diseases such as inflammatory bowel disease (IBD) and chronic kidney disease (CKD). Key Topics Covered: The biggest challenges in immunology drug discovery – and how to overcome them Breakthrough 3D tissue models for vascular inflammation, IBD, and CKD research Case studies showcasing real-world applications in immunology drug testing How advanced microphysioloigical systems improve therapeutic efficacy predictions How 3D human tissue models can enhance drug screening and mechanistic insights.

The article compares angiogenesis and vasculogenesis, highlighting the limitations of current in vitro models. It calls for more physiologically relevant models to better replicate blood vessel formation processes.

The article emphasizes the need for advanced in vitro angiogenesis models like OrganoPlate® to study blood vessel growth in disease, offering scalable, high-throughput solutions for drug discovery and personalized assays.

Join the speakers of our webinar to learn how we employed the OrganoPlate® platform, a standardized and high-throughput capable organ-on-chip platform, in conjunction with the Tecan Spark® Cyto multimode plate reader in an assay to investigate the toxic effect of snake venom on endothelial tubules grown in the chip

In this webinar, you will learn how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules. Namely, the P-glycoprotein and the combined activities of Multidrug Resistance Proteins 2 and 4.