Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
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Better models for studying nephrotoxicity are desperately needed. Current in vivo or in vitro models do not always suffice. They can lack throughput, physiological relevance, and predictive power.In the first webinar of this series, you learned how to develop an in vitro 3D model of fully polarized renal proximal tubular epithelial cells expressing active transporters that are necessary for your studies in the OrganoPlate®. In this webinar, you will learn how this model was further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules. Namely, the P-glycoprotein and the combined activities of Multidrug Resistance Proteins 2 and 4.Imagine your nephrotoxicity studies bringing reliable, consistent, and physiologically relevant results quickly and by using human cell lines. The OrganoPlate® platform is already successfully being used by the top 10 pharma as well as by hundreds of academic researchers worldwide.
Webinar Highlights:
- Choosing the right cell line and culture platform for reliable 3D in vitro nephrotoxicity studies
- Evaluating if your 3D in vitro model is physiologically relevant
- Studying drug transport in 3D
- Qualifying your in vitro 3D renal proximal tubule model with clinically relevant compounds
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.
Webinar: Screening of renal drug-transporter interactions in a 3D Human Proximal-Tubule-on-a-Chip
Discover how we developed a fully polarized 3D in vitro renal proximal tubule model and further validated through drug-drug interaction studies focusing on two important efflux mechanisms in renal proximal tubules.