Unravelling Oncology TherapeuticsCancer continues to be a leading cause of mortality worldwide, accounting for nearly 10 million deaths in 2020. Alongside growing incidence rates each year, knowledge of molecular and tumor biology has also increased and notably affected cancer treatment paradigms. Until recently, cancer therapeutics focused on four main types of treatment: surgery, chemotherapy, radiotherapy, and targeted therapy. However, over the past ten years, immunotherapy has emerged as a novel and revolutionary approach to cancer treatment.In this roundtable discussion, immuno-oncology decision-making experts from pharma, biotech, and academia discuss the complexity of cancer and its diagnosis.The panel also share their perspectives on current and future approaches towards cancer management and explore paradigm shifts surrounding immuno- and precision oncology.Key discussion points:- The complexity of cancer: the interplay between a tumor and its microenvironment- Current therapeutic approaches in oncology: their successes and failures- The role of the immune system in tumor growth of metastases- How to develop the best near-patient models in immuno-oncology- The most promising novel therapeutic approaches towards cancer