Predictive ADME & Toxicity Testing Services
MIMETAS delivers physiologically-relevant, 3D human tissue models at scale that provide reliable and early insights into compound safety and pharmacokinetics.
Human-Centric Models to Assess Drug Safety, Transport, and Tolerability
Our 3D tissue models provide human data to accelerate and de-risk programs for therapeutic modalities like small molecules, bi-specific antibodies, ADCs, and cell & gene therapy.
Explore some of our featured applications below.
Blood-Brain Barrier (BBB)
Built on primary brain microvascular endothelial cells, with optional co-culture of pericytes, astrocytes, and neurons, the BBB model supports studies on antibody transcytosis, small molecule transport, and barrier integrity.
Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Study neurotoxicity induced by chemotherapeutics and ADCs (Chemotherapy-Induced Peripheral Neuropathy - CIPN) and accurately identify safer alternatives by tracking axonal degeneration and cell health in human neurons.
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Gastrointestinal Toxicity
Our 3D human colon organoid model simulates dynamic epithelial and barrier integrity under flow, providing a reliable system for assessing GI toxicity in response to oral drugs and biologics.
Kidney
MIMETAS’ glomerular and proximal tubule, and ASC-derived organoids provide platforms for safety testing, mechanistic insights, and in-depth analysis of renal absorption, metabolism, and excretion.
Liver
MIMETAS’ liver model accurately replicates liver architecture, metabolism, and microenvironment, enabling studies on DILI/iDILI, gene therapy (LNP/AAV) delivery and safety, and liver metabolism.
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Vasculature
Perfusable endothelial tubules used for investigating vascular toxicity, assessing barrier function, marker expression and phenotypic analysis. Immune cells can be integrated to study vascular inflammation.
Built for High-Throughput, High-Impact Decision Making, At Scale
By recreating the complexity of human tissue environments, MIMETAS helps you evaluate drug safety and performance with confidence – before entering the clinic.
MIMETAS’ models enable human-relevant ADME/Tox studies by integrating:
Perfused endothelial and epithelial barriers
Organ-specific stromal and immune components
Functional outputs—cell viability, morphology, and permeability
Multiplex readouts for mechanistic insight
