Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent neurological side-effect of several widely-used chemotherapeutics. To facilitate in vitro toxicity assessment of drug leads before the reach the clinic, we describe a robust PN model of motor neurons in a 3D microfluidic platform. Our model is tested for its ability to recapitulate nerve damage caused by compounds with known CIPN side effects in the clinicPoster Development of a 3D microphysiological placenta barrier in vitro model as a tool for drug transport studiesIn this poster, we present a Chemotherapy-Induced Peripheral Neuropathy on-a-chip. This model was developed to mimic chemotherapy-induced peripheral neuropathy (CIPN) in human iPSC-derived motor neurons, offering a scalable and automation-compatible solution for assessing the neurotoxicity of chemotherapeutic drugs. By demonstrating dose-dependent and time-sensitive damage to neuronal networks, our model stands as a critical tool in the development of safer chemotherapy treatments, facilitating enhanced patient care and recovery pathways.