OrganoREADY®

OrganoReady® Colon Organoid

Delivered as perfusable, leak-tight tubules with a functional intestinal barrier.

The OrganoReady® Colon Organoid is an adult stem cell–derived, ready-to-use HUB colon organoid model delivered as perfusable, leak-tight tubules with a functional intestinal barrier. This assay-ready format enables accurate and reproducible gastrointestinal (GI) toxicity testing, addressing a critical need in preclinical drug development.

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Specifications

Each OrganoReady Colon Organoid comes pre-seeded with 40 or 64 ready-to-use colon organoids tubules grown against validated Collagen-I with stable barriers.

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Plate type: OrganoPlate® 3-lane 64 or 40
Configuration: colon organoid tubules against Collagen-1
HUB license (single-use) included
Access: Apical and basal
Recovery time: Functional barrier re-forms within a few days post-arrival; no additional seeding or preparation required
Intestinal barrier integrity
GI toxicity
Inflammation
Nutrient and metabolite transport
Food safety
Pre-biotics and microbiome interactions

Applications

The OrganoReady Colon Organoid model replicates key features of the human intestinal tissue, enabling a range of disease-relevant and preclinical assays. All applications benefit from our OrganoTEER system for barrier function measurement.

Learn more about the OrganoTEER®

Validation

The OrganoReady Colon Organoid model demonstrates adult intestinal tissue characteristics, including a mature epithelial phenotype with apical–basolateral polarity, functional transporter activity, and proliferative profile.

Microscopic view of colorful cells with blue, green, and red fluorescent staining
Organoid tubules comprise all major gut cell subtypes, including enterocytes, goblet cells, proliferative cells, and stem cells
Blurry digital glitch with colorful blue, green, and red distorted pixels
Colon organoids are fully polarised with apical brush borders, BCRP, and PgP transporter expression and basal Integrin β4
Long-term viability and reproducible barrier function (TEER) that can be modulated with toxicants

Resources

Webinar on intestinal toxicity screenings using stem cell-derived organoids
Webinar: Revolutionizing Intestinal Toxicity with Perfusable Adult Stem Cell-Derived Organoids
This webinar presents the OrganoReady® Colon Organoid as a scalable, adult stem cell–derived model to advance intestinal toxicity testing and disease modeling with improved translational relevance.
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App Note: Predicting gastrointestinal toxicity using adult stem cell-derived OrganoReady Colon Organoid with functional multiplexed assays
This AppNote presents the OrganoReady® Colon Organoid as a ready-to-use, adult stem cell–derived 3D model for predicting drug-induced gastrointestinal toxicity using multiplexed, translatable assays.
Read the App Note
Poster: Automated Toxicology Screening in Assay-Ready Colon Organoid Model to Evaluate Therapy-Induced Gastrointestinal Toxicity
This poster presents a 3D colon organoid model for high-throughput gastrointestinal toxicity screening, featuring adult stem cell–derived architecture, perfusion, and mechanistic readouts.
Read the Poster

How to Access Our OrganoReady® Colon Organoid

Services

MIMETAS provides tailored, fee-for-service solutions to support therapy selection and risk assessment. Using the OrganoReady® Colon Organoid model, we offer scalable assays for disease modeling, compound prioritization and safety, as well as DMPK ranking.

Shipped Product

The OrganoReady® Colon Organoid is offered as a ready-to-use model shipped directly to your lab, complete with culture media and optimized protocols. After a short recovery, the perfusable tubules are assay-ready, ideal for evaluating gut physiology and gastrointestinal toxicity studies.

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