Publications

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Explore peer-reviewed publications from MIMETAS scientists, customers, and collaborators to support your discovery journey.

2025 Cytokine-Induced Barrier Dysfunction and Lipid Signaling in a Gut-On-Chip Model
2025 Bifidobacterium Longum subsp. infantis and Lacticaseibacillus Rhamnosus GG Protect Intestinal Epithelium Against Inflammation-Mediated Damage in an Immunocompetent In-Vitro Model
2025 High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
2025 A Novel Human Distal Tubuloid-on-a-Chip Model for Investigating Sodium and Water Transport Mechanisms
2025 ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells
2025 Insights into the Cellular and Molecular Mechanisms behind the Antifibrotic Effects of Nerandomilast
2025 Changes in Generations of PAMAM Dendrimers and Compositions of Nucleic Acid Nanoparticles Govern Delivery and Immune Recognition
2025 Perfusable Brain Microvascular Network-On-Chip Model to Study Flavivirus NS1-Induced Endothelial Dysfunction
2025 A Postbiotic Derived from Lactobacillaceae Protects Intestinal Barrier Function in a Challenge Model Using Colon Organoid Tubules
2025 Microfluidic artery-on-a-chip model with unidirectional gravity-driven flow for high-throughput applications
2025 Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration
2025 A Postbiotic Derived from Lactobacillaceae Protects Intestinal Barrier Function in a Challenge Model Using Colon Organoid Tubules
2024 Characterizing Microbubble-Mediated Permeabilization in a Vessel-on-a-Chip Model
2025 Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity
2025 Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model
2024 A microvascularized in vitro liver model for disease modeling and drug discovery
2025 Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells
2024 An immunocompetent human kidney on-a-chip model to study renal inflammation and immune-mediated injury
2024 A microphysiological assay for studying T-cell chemotaxis, trafficking and tumor killing
2024 High-throughput Bronchus-on-a-Chip system for modeling the human bronchus
2024 Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model
2024 Modeling of Blood–Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research
2024 Modeling cancer-associated hypercoagulability using glioblastoma spheroids in microfluidic chips
2024 Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products
2024 Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules
2024 The microbial metabolite p-cresol compromises the vascular barrier and induces endothelial cytotoxicity and inflammation in a 3D human vessel-on-a-chip
2024 Protocol for a placenta-on-a-chip model using trophoblasts differentiated from human induced pluripotent stem cells
2024 Allogeneic bone marrow mesenchymal stem cell-derived exosomes alleviate human hypoxic AKI-on-a-Chip within a tight treatment window
2024 Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system
2024 Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products
2024 Modeling of Blood–Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research
2024 Modeling cancer-associated hypercoagulability using glioblastoma spheroids in microfluidic chips
2024 Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities
2024 Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model
2024 Development of a cancer metastasis-on-chip assay for high throughput drug screening
2024 Cortical-Organoid Grafted Microvascular Bed on a Chip
2024 A three-dimensional vessel-on-a-chip model to study Puumala orthohantavirus pathogenesis
2024 A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis
2024 A high-throughput gut-on-chip platform to study the epithelial responses to enterotoxins
2023 Vascular inflammation on a chip: A scalable platform for trans-endothelial electrical resistance and immune cell migration
2023 A “Kidney-on-the-Chip” Model Composed of Primary Human Tubular, Endothelial, and White Blood Cells
2023 Quantify permeability using on-a-chip models in high-throughput applications
2023 Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
2023 Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay
2023 The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model
2023 The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease
2023 Microfluidic models of the neurovascular unit: a translational view
2023 Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80
2023 Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Migration
2023 Human vasculature-on-a-chip with macrophage-mediated endothelial activation: The biological effect of aerosol from heated tobacco products on monocyte adhesion
2023 Gut-on-a-Chip Models: Current and Future Perspectives for Host–Microbial Interactions Research
2023 Healthy and diseased placental barrier on-a-chip models suitable for standardized studies
2023 Human BBB-on-a-chip reveals barrier disruption, endothelial inflammation, and T cell migration under neuroinflammatory conditions
2022 Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
2023 Effects of short-chain per- and polyfluoroalkyl substances on toxicologically relevant gene expression profiles in a liver-on-a-chip model
2023 Dose and route dependent effects of the mycotoxin deoxynivalenol in a 3D gut-on-a-chip model with flow
2023 Development of a human iPSC-derived placental barrier-on-chip model
2023 Development of a 3D Perfused In Vitro System to Assess Proangiogenic Properties of Compounds
2023 A model of hepatic steatosis with declined viability and function in a liver-organ-on-a-chip
2023 A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
2023 Cortical spheroid on perfusable microvascular network in a microfluidic device
2023 Bone on-a-chip: a 3D dendritic network in a screening platform for osteocyte-targeted drugs
2023 A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment
2023 3D dynamic cultures of HGSOC organoids to model innovative and standard therapies
2022 Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging
2022 Modelling and Prevention of Acute Kidney Injury through Ischemia and Reperfusion in a Combined Human Renal Proximal Tubule/Blood Vessel-on-a-Chip
2022 In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
2022 Liver-on-a-chip devices: the pros and cons of complexity
2022 3D microfluidics-assisted modeling of glucose transport in placental malaria
2022 Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs
2022 High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis
2022 Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-culture from Human Stem Cells
2022 Evaluation of immunotherapies improving macrophage anti-tumor response using a microfluidic model
2022 Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation‑on‑a‑chip model
2022 Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics screening platform
2022 Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells
2022 Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells
2022 Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model
2022 An in silico Model of T Cell Infiltration Dynamics Based on an Advanced in vitro System to Enhance Preclinical Decision Making in Cancer Immunotherapy
2022 A versatile multiplexed assay to quantify intracellular ROS and cell viability in 3D on-a-chip models
2022 A Three-Dimensional Brain-on-a-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes
2022 A 3D Perfusable Platform for In Vitro Culture of Patient Derived Xenografts
2021 The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma
2021 A directional 3D neurite outgrowth model for studying motor axon biology and disease.
2021 Intestinal Epithelium Tubules on a Chip
2021 Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
2021 Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening
2021 Long-Lived Human Lymphatic Endothelial Cells to Study Lymphatic Biology and Lymphatic Vessel/Tumor Coculture in a 3D Microfluidic Model
2021 Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies
2021 High Throughput Transepithelial Electrical Resistance (TEER) Measurements on Perfused Membrane-Free Epithelia
2021 Generation of a Glomerular Filtration Barrier on a Glomerulus-on-a-Chip Platform
2021 Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.
2021 Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip
2021 Adoption of Organ-on-Chip Platforms by the Pharmaceutical Industry
2021 A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions
2021 A Microfluidics-Based Screening Tool to Assess the Impact of Blood Plasma Factors on Microvascular Integrity
2021 A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease
2021 A 3D Renal Proximal Tubule-on-Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy
2021 A 3D Microfluidic Liver Model for High Throughput Compound Toxicity Screening in the OrganoPlate®
2020 Three-Dimensional Brain-on-Chip Model Using Human iPSC-Derived GABAergic Neurons and Astrocytes: Butyrylcholinesterase Post-Treatment for Acute Malathion Exposure
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