OrganoReady®
Blood Vessel HUVEC
OrganoReady® Blood Vessel HUVEC is a ready-to-use primary human vascular model delivered as perfusable, leak-tight HUVEC tubules. These tubules feature apical and basal access without the use of artificial membranes and develop a functional barrier enabling direct compound exposure. The model is suitable for therapeutic screening to predict toxicity and understand mechanisms of endothelial dysfunction and inflammation.
Specifications
Each OrganoReady Blood Vessel HUVEC comes pre-seeded with 40 or 64 ready-to-use HUVEC tubules grown against validated Collagen-I with stable barriers.
Cell Type: Human umbilical vein endothelial cells (HUVECs)
Format: OrganoPlate® 3-lane 64 or 40
Configuration: HUVEC tubules against Collagen-I
Access: Apical and basolateral, membrane-free
Recovery Time: Functional barrier re-forms within a few days post-arrival; no additional seeding or preparation required
Assessment of barrier function
Vascular toxicity screening
Inflammatory response analysis
Immune cell adhesion assays
Applications
The OrganoReady Blood Vessel HUVEC model supports a range of assays relevant to vascular and endothelial biology. All applications benefit from our OrganoTEER system for barrier function measurement.
Validation
The OrganoReady® Blood Vessel HUVEC model features expression of key endothelial markers such as VE-cadherin, CD31, ICAM-1 reflecting tight junction formation, vascular identity and immune cell adhesion properties.
Blood Vessel HUVEC shows lumen formation and confirms the 3D architecture of endothelial tubules (VE-cadherin)
Demonstrated endothelial barrier integrity and inflammatory response in the Blood Vessel-on-a-Chip model (VE-cadherin, ICAM-1)
Confirmed tox-induced morphological disruption in the endothelial vessels (Calcein-AM, Actin and Propodium Iodide)
App Note: Snake Venom Toxicity
High-Throughput Toxicity Assessment in OrganoReady® Blood Vessel HUVEC: This AppNote describes a high-throughput assay using the OrganoReady® Blood Vessel model to study vascular toxicity of snake venoms. The 3D perfused model enables real-time assessment of endothelial barrier function, viability, and morphology.
How to Access Our OrganoReady® Blood Vessel HUVEC
Services
MIMETAS offers customized, fee-for-service solutions to support immune modulator development, therapy optimization, and safety assessment. The blood vessel HUVEC model supports co-culture with immune cells and enables functional assays such as immune cell transmigration.
Shipped Product
The OrganoReady® Blood Vessel HUVEC is offered as a ready-to-use model shipped directly to your lab, complete with culture media and optimized protocols. After a short recovery, the perfusable tubules are assay-ready, ideal for vascular toxicity and inflammatory studies.