• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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Blood-Brain Barrier Toxicity Assay

OrganoServicesTM are available for multiple assays to allow compound profiling and/or screening in human-relevant, complex 3D tissue models.

The blood-brain barrier (BBB) ensures a​ homeostatic environment for the central nervous system (CNS) and is essential for healthy brain functioning. When developing new therapeutic treatments and assessing drug toxicity, it is crucial to understand BBB function by studying its absorption, transport, and permeability. To study BBB barrier integrity in a high-throughput manner, we developed a robust human brain microvascular endothelial cells HBMEC BBB model in the OrganoPlate® combined with a validated barrier integrity assay and usage of the OrganoTEER®, which rapidly measures the transepithelial electrical resistance (TEER) of 64 endothelial cultures at once.

Blood-Brain Barrier Toxicity Assay OrganoService offers:

  • Screening of your compounds in a validated, physiologically relevant BBB model​
  • Screening of up to 13 compounds in one concentration per OrganoPlate​
  • 4 technical replicates and 3 control samples​
  • Raw and normalized TEER values in a clear data report​
  • Extend the compound screen with more plates, in case a larger screen is desired

An example of an application that can be performed using this OrganoServiceTM is to evaluate concentration-dependent disruption of blood-brain barrier integrity ​following compound exposure.


About Perfused Tubules OrganoTEER

 

Service details

About Blood-Brain Barrier Small Molecule Transport Assay


Kickstart drug toxicity studies in a physiologically relevant 3D human BBB model
Focus directly on analyzing the data, while we set up and perform your toxicity assay in a perfusable human brain microvascular endothelial model​

​Multiple time point measurements​
High sensitivity of drug-induced barrier disruptions with optimized time point measurements​

​Data reporting in one go
Receive a clear data report and raw data sheets​

Robust and reproducible assay​
Automated workflow ensures consistent performance and data quality​
​
TEER evaluation under physiological conditions
Barrier integrity data are obtained​ by OrganoTEER®, the only instrument that can capture barrier function of 3D tissue models ​

​Complement your BBB toxicity studies with additional drug permeability studies​
Study transport and penetration kinetics across the BBB of your compounds with our OrganoService BBB Small Molecule Transport Assay​

Service flyer Contact us for more info

Get inspired


Webinar
(2020) OrganoTEER®: Know Your Barriers. Fast.

App Note
Perfused primary human blood-brain barrier in Mimetas' OrganoPlates

Publication
2018 A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport. Fluids Barriers CNS. Wevers et al.

Blog
2D Versus 3D Cell Cultures: Advantages and Disadvantages

All OrganoServices

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us

Living innovation

What customers say
'
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform

James Sabry, Global Head
Roche Pharma Partnering

The 'I' in MIMETAS
'
Tackling challenges together.

Linda Gijzen
Scientific Project Lead

What customers say
'
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "

Cezmi Akdis
Director SIAF
University Zurich

What customers say
'
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.

Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA

The 'I' in MIMETAS
Chiwan Chiang
Marketing Specialist
'
A day without
laughter is a day wasted.
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What customers say
'
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data

Scientist
From a top pharma

The 'I' in MIMETAS
Jos Joore
CEO
'
We want to
empower research on complex tissue biology.
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What customers say
'
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!

Scientist
From a top pharma

The 'I' in MIMETAS
Nienke Wevers
Senior Scientist
'
Nothing ventured, nothing gained.
Read more
What customers say
'
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.

Scientist
From a top commercial organization

The 'I' in MIMETAS
Henriëtte Lanz
Director of Model Development
'
It should be
mandatory to
socialize with colleagues.
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What customers say
'
Organoplates opened avenues that were before considered unreachable

Laura Perin, PhD
Children’s Hospital Los Angeles

The 'I' in MIMETAS
Bas Trietsch
Chief Technology Officer
'
We try to help
each other
as a team.
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The 'I' in MIMETAS
Jacquelien Ten Dam
Chief Financial Officer
'
It always seems impossible until it’s done.
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The 'I' in MIMETAS
Paul Vulto
CEO
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Leveraging who you are, is the key to making a difference!
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The 'I' in MIMETAS
Linda Gijzen
Scientific Project Lead
'
Tackling challenges together.
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The 'I' in MIMETAS
Tina Thakkar
Associate Director of Sales
'
It is not really
work if you are
having fun.
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The 'I' in MIMETAS
Liis Rannamäe
Laboratory Technician
'
Can be summarized in three words - engaging, playful, and innovative.
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The 'I' in MIMETAS
Mieke Doornbos
Vice President Sales & Marketing
'
Celebrate
good times.
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The 'I' in MIMETAS
Frederik Schavemaker
Product Design Engineer
'
Pioneering, bringing the best solutions
for scientific
discovery.
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The 'I' in Mimetas
Remko van Vught
Vice President Business Development
'
Making
a difference
together.
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The 'I' in MIMETAS
Lenie van den Broek
Director Biology Discovery
'
Dynamic and innovative - each day holds a surprise.
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The 'I' in Mimetas
Arnaud Nicolas
Associate Director TechCore
'
Own your flaws.
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Latest Whitepaper
'
Closing the Translational Gap in Cancer Drug Discovery with Comprehensive Tumor Models

Discover insights from six oncology applications of MIMETAS’ 3D tumor models.


Download the whitepaper

New Webinar
'
Phenotypic Disease Modeling for Immuno-Oncology: Putting Targets into Patient Context


Now available on demand.

Watch it here

Press Release
'
MIMETAS and Astellas Enter into Strategic Partnership on Immuno-oncology

The partnership comprises utilizing MIMETAS’ comprehensive tumor models to support the next generation of immuno-oncological therapies.

Read the full article here

News Article
'
First Large-scale Phenotypic Screen Using Organ-on-a-Chip

Leveraging a 3D angiogenesis assay, MIMETAS executed a 1537 kinase inhibitor library screen.


Read the article

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