• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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App Note: Perfused primary human blood-brain barrier in MIMETAS OrganoPlates

Mimetas’ OrganoPlates® are microfluidic cell culture plates that enable culturing of a range of miniaturized 3D organ and tissue models. Here we describe the development of a primary human model of the blood-brain barrier (BBB) comprising a microvessel of brain endothelial cells, supported by astrocytes and pericytes. The model shows expression of adherens- and tight junction proteins, barrier formation, and functional P-gp transport. The platform’s compatibility with standard laboratory equipment and automation makes this perfused BBB-on-a-chip amenable to high-throughput screening purposes.

Want to learn more? Download the app note below!

 

Download the app note here

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