Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and toxicity.
Authors: Martijn Wilmer, Chee Ping Ng, Henriëtte Lanz, Paul Vulto, Laura Suter-Dick and Roos Masereeuw