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  • organ on a chip

  • organ on a chip

  • organ on a chip

  • organ on a chip

Organ-on-a-Chip. Now.

We all want better medicines, that’s obvious. To make this possible, you need better disease models. They should be fully human and physiologically relevant. Truly informative tools, compatible with compounds and with high-throughput readout equipment. And of course you need them today, rather than tomorrow.

Development of 3D tissue models

organ on a chip
Human tissue models
Membrane-free co-culture
Epithelial boundaries
Culture up to months
MIMETAS develops human organ-on-a-chip models to specification. Unique OrganoPlate® technology allows for perfused 3D cell culture and tissue models. Our aim is to transfer complete, working models of human tissues to our partners and customers, including customized OrganoPlates®.

Co-culture and boundary tissues

organ on a chip
Unique OrganoPlate®
Pump-free perfusion flow
Defined height for easy imaging
No special equipment needed
OrganoPlates® feature pump-free perfusion for long-term culture of even sensitive cell types such as human iPS neurons. The horizontal lane layout supports adjacent co-culture and functional epithelial boundary culture for a range physiologically relevant tissue models.

High throughput and compatible

OrganoPlate™
High-throughput
SBS plate format
Low compound absorbance
For all plate readers
We have designed OrganoPlates® with compatibility in mind, based on industry standard microplate formats. With 96 cultures per plate, we set a new standard for throughput in perfused 3D cell culture systems, compatible with a range of readouts, assays and human tissues.

New publications: Review article on Kidney-on-a-Chip in Trends in Biotechnology and Blood-Brain-Barrier in Tissue Barriers

Kidney-on-a-chip

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and toxicity.

Authors: Martijn Wilmer, Chee Ping Ng, Henriëtte Lanz, Paul Vulto, Laura Suter-Dick and Roos Masereeuw

Blood-brain-barrier

The microvasculature of the brain forms a protective blood-brain barrier (BBB) that ensures a homeostatic environment for the central nervous system (CNS). The barrier properties of the brain endothelial cells are maintained by cells surrounding the capillaries, such as astrocytes and pericytes. Together with the endothelium and a basement membrane, these supporting cells form the neurovascular unit (NVU). Accumulating evidence indicates that the supporting cells of the NVU release a wide variety of soluble factors that induce and control barrier properties in a concentration-dependent manner. The review provides a comprehensive overview of how such factors, called morphogens, influence BBB integrity and functioning.

Authors: Nienke Wevers and Helga de Vries

The working principles of OrganoPlates®

OrganoPlates® are microfluidics‐based 3D culture plates. This video demonstrates their working principles using PhaseGuide™-technology and ease-of-use with manual or robotic operation. Based on industry-standard 384-well microplates, compatibility with microscopy and readout equipment, including confocal microscopy and luminescent readers is guaranteed.

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