• organ on a chip

  • organ on a chip

  • organ on a chip

  • organ on a chip


Development of 3D tissue models

organ on a chip
3D disease and tissue models
Membrane-free co-culture
Epithelial boundaries
Culture up to months
MIMETAS develops organ on a chip models to specification. Unique OrganoPlate™ technology allows for perfused 3D cell culture and tissue models. Our aim is to transfer complete, working models to our partners and customers, including customized OrganoPlates™.

Co-culture and boundary tissues

organ on a chip
Unique OrganoPlate™
Pump-free perfusion flow
Defined height for easy imaging
No special equipment needed
OrganoPlates™ feature pump-free perfusion for long-term culture of even sensitive cell types such as neurons. The horizontal lane layout supports adjacent co-culture and functional epithelial boundary culture for a range physiologically relevant tissue models.

High throughput and compatible

SBS plate format
Low compound absorbance
For all plate readers
We have designed OrganoPlates™ with compatibility in mind, based on industry standard microplate formats. With 96 cultures per plate, we set a new standard for throughput in perfused 3D cell culture systems, compatible with a range of readouts and assays.

MIMETAS corporate sponsor of first Organ on a Chip World Congres in Boston

The first ever Organ-on-a-Chip World Congress focuses on Organ-on-a-Chip technology, Biofabrication and 3D-Bioprinting in the life sciences. The conference will be held in Boston, MA on 8-9 July 2015, organized by Selectbio.

MIMETAS is corporate sponsor of this inaugural conference.

Read more here>

3D-cultured iPS neurons firing in OrganoPlate

Spontaneous firing of 2-month-old neurons imaged by Fluo-4 calcium dye.

Spontaneously electrophysiologically active dopaminergic neurons in OrganoPlates™

In collaboration with the University of Luxembourg, induced human pluripotent stem cells have been successfully differentiated into dopaminergic neurons in the OrganoPlate™. The differentiation process took 30 days, after which in situ morphological, immunocytochemical and calcium imaging confirmed the presence of dopaminergic neurons that were spontaneously electrophysiologically active, a characteristic feature of nigrostriatal dopaminergic neurons in vivo. These results have been published in the Lab on a Chip journal. Direct download of the pdf here.

The working principles of OrganoPlate™-based 3D tissue models

OrganoPlates™ are microfluidics‐based 3D culture plates. This video demonstrates their working principles using PhaseGuide™-technology and ease-of-use with manual or robotic operation. Based on industry-standard 384-well microplates, compatibility with microscopy and readout equipment, including confocal microscopy and luminescent readers is guaranteed.