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Blood Vessel Models
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Explore peer-reviewed publications

2024 High-throughput Bronchus-on-a-Chip system for modeling the human bronchus. Mori et al.

2024 A microvascularized in vitro liver model for disease modeling and drug discovery. Bonanini et al.

2024 The microbial metabolite p-cresol compromises the vascular barrier and induces endothelial cytotoxicity and inflammation in a 3D human vessel-on-a-chip. Mankhong et al.

2024 Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities. Maulana et al.

2024 Cortical-Organoid Grafted Microvascular Bed on a Chip. Uzoechi et al.

2024 A three-dimensional vessel-on-chip model to study Puumala orthohantavirus pathogenesis. Noack et al.

2024 Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model Uzoechi et al.

2024 Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system. Harada et al.

2024 Modeling of Blood–Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research. Ohbuchi et al.

2024 Modeling cancer-associated hypercoagulability using glioblastoma spheroids in microfluidic chips. Kapteijn et al.

2024 Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products. Chapman et al.

2024 Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules. Bittenbinder et al.

2024 A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis. Riddle et al.

2024 A high-throughput gut-on-chip platform to study the epithelial responses to enterotoxins. Morelli et al.

2024 Liver-on-a-chip devices: the pros and cons of complexity. Dalsbecker et al.

2024 Protocol for a placenta-on-a-chip model using trophoblasts differentiated from human induced pluripotent stem cells. Lermant et al.

2024 Development of a cancer metastasis-on-chip assay for high throughput drug screening. Ozer et al.

2023 Development of a 3D Perfused In Vitro System to Assess Proangiogenic Properties of Compounds. Alm et al.

2023 A model of hepatic steatosis with declined viability and function in a liver-organ-on-a-chip. Wiriyakulsit et al.

2023 Microfluidic models of the neurovascular unit: a translational view. Wevers & De Vries.

2023 Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80. Ogulur et al.

2023 Cortical spheroid on perfusable microvascular network in a microfluidic device. Russel et al.

2023 Bone on-a-chip: a 3D dendritic network in a screening platform for osteocyte-targeted drugs. Lipreri et al.

2023 Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on toxicologically relevant gene expression profiles in a liver-on-a-chip model. Solan et al.

2023 Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration. Wisdom et al.

2023 Human BBB-on-a-chip reveals barrier disruption, endothelial inflammation, and T cell migration under neuroinflammatory conditions. Nair et al.

2023 Development of a human iPSC-derived placental barrier-on-chip model. Lermant et al.

2023 Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies Leclercq-Cohen et al.

2023 The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease. de Rus Jacquet et al.

2023 A Perfused In Vitro Human iPSC-Derived Blood-Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies. Burgio et al.

2023 A “Kidney-on-the-Chip” Model Composed of Primary Human Tubular, Endothelial, and White Blood Cells. Marschner et al.

2023 Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay. Soragni et al.

2023 Human vasculature-on-a-chip with macrophage-mediated endothelial activation: The biological effect of aerosol from heated tobacco products on monocyte adhesion. Ohashi et al.

2023 3D dynamic cultures of HGSOC organoids to model innovative and standard therapies. Cavarzerani et al.

2023 The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model. Geyer et al.

2023 Healthy and diseased placental barrier on-a-chip models suitable for standardized studies. Rabussier et al.

2023 Gut-on-a-Chip Models: Current and Future Perspectives for Host–Microbial Interactions Research. Morelli et al.

2023 Gut epithelial barrier damage caused by dishwasher detergents and rinse aids. Ogulur et al.

2023 Dose and route dependent effects of the mycotoxin deoxynivalenol in a 3D gut-on-a-chip model with flow. Pöschl et al.

2023 A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment. Geyer et al.

2023 Vascular inflammation on a chip: A scalable platform for trans-endothelial electrical resistance and immune cell migration. Ehlers et al.

2023 Quantify permeability using on-a-chip models in high-throughput applications. Soragni et al.

2022 A 3D Perfusable Platform for In Vitro Culture of Patient Derived Xenografts. Sablatura et al.

2022 Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging. Weller et al.

2022 High‑throughput 3D microvessel‑on‑a‑chip model to study defective angiogenesis in systemic sclerosis. Kramer et al.

2022 A versatile multiplexed assay to quantify intracellular ROS and cell viability in 3D on-a-chip models. Soragni et al.

2022 Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model. Verma et al.

2022 A Three-Dimensional Brain-on-a-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes. Liu et al.

2022 3D microfluidics-assisted modeling of glucose transport in placental malaria. Mosavati et al.

2022 In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed. Bonanini et al.

2022 Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells. M He et al.

2022 Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-Culture From Human Stem Cells. Marzano et al.

2022 An in silico Model of T Cell Infiltration Dynamics Based on an Advanced in vitroSystem to Enhance Preclinical Decision Making in Cancer Immunotherapy. Lewin et al.

2022 Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Kurosawa et al.
2022 Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model. Riddle et al.
2022 Evaluation of immunotherapies improving macrophage anti-tumor response using a microfluidic model. Chernyavska et al.
2022 Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics screening platform. Jung et al.
2022 Modelling and Prevention of Acute Kidney Injury through Ischemia and Reperfusion in a Combined Human Renal Proximal Tubule/Blood Vessel-on-a-Chip., Vormann M. et al.

2022 Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs., Fengler S. et al.

2021 The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma. Avnet et al.

2021 Adoption of organ-on-chip platforms by the pharmaceutical industry., Paul Vulto & Jos Joore.

2021 Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening. Marlene Geyer & Karla Quieroz.

2021 Modeling ischemic stroke in a triculture neurovascular unit on-a-chip, Wevers N. et al.

2021 A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System which Better Mimics in Vivo Physiological Conditions., Hagiwara Y. et al.

2021 Intestinal Epithelium Tubules on a Chip., Kosim K. et al.

2021 A Microfluidics-Based Screening Tool to Assess the Impact of Blood Plasma Factors on Microvascular Integrity., Junaid A. et al.

2021 Generation of a Glomerular Filtration Barrier on a Glomerulus-on-a-Chip Platform., Perin L. et al.

2021 Long-Lived Human Lymphatic Endothelial Cells to Study Lymphatic Biology and Lymphatic Vessel/Tumor Coculture in a 3D Microfluidic Model., Frenkel N. et al.

2021 High-throughput 3D cell migration assays in organ-on-a-chip technologies., Goubert D. et al.

2021 A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease., De Haan L. et al.

2021 A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy., Naik S et al.

2021 Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment. Igarashi et al.

2021 High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia., Nicolas et al.

2021 Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment. Tachibana et al.

2021 Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip., Gijzen L. et al.

2021 Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies., Vormann M. et al.

2021 A directional 3D neurite outgrowth model for studying motor axon biology and disease., Spijkers X. et al.

2021 A 3D Microfluidic Liver Model for High Throughput Compound Toxicity Screening in the OrganoPlate®., Bircsak K. et al.
2020 Development of a human primary gut-on-a-chip to model inflammatory processes., Beaurivage C. et al.
2020 Human Retinal Microvasculature-on-a-Chip for Drug Discovery., Ragelle H. et al.
2020 Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells., Roudnicky F. et al.

2020 Neutrophilic infiltration in organ-on-a-chip model of tissue inflammation., Gjorevski N. et al.

2020 Metabolic response of blood vessels to TNFα., Junaid A. et al.
2020 Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells., Naumovska E. et al.

2020 Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening., van Duinen V. et al.

2020 Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. Marx et al.

2020 An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes., Gijzen L. et al.

2020 Three-dimensional Brain-On-Chip Model Using Human iPSC-derived GABAergic Neurons and Astrocytes: Butyrylcholinesterase Post-Treatment for Acute Malathion Exposure., PLoS One, Lumei L. et al.
2020 Snake Venom Gland Organoids., Cell, Post Y. et al.
2020 Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. BBA, J. Vriend et al.

2019 Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening. Liu et al.

2019 Development of a Gut-On-A-Chip Model for High Throughput Disease Modeling and Drug Discovery., IJMS, C. Beaurivage et al.
2019 A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Nature Communications. A. Petrosyan et al.
2019 Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro., van Duinen V. et al.
2019 Automated microfluidic cell culture of stem cell derived dopaminergic neurons. Scientific Reports. Khalid I. W. Kane et al.
2019 Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nature Biotech. Frans Schutgens et al.
2019 Differentiation of the human liver progenitor cell line (HepaRG) on a microfluidic?based biochip. Advanced Science. Mi Jang et al.
2018 Determination of the rheological properties of Matrigel for optimum seeding conditions in microfluidic cell cultures, AIP Advances. Kane et al.
2018 3D Cultures of Parkinson's Disease Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science, Bolognin et al.
2018 Perfused 3D angiogenic sprouting in a high-throughput in vitro platform. Angiogenesis. Van Duinen et al.
2018 A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport. Fluids Barriers CNS. Wevers et al.
2018 Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. Vormann et al.
2018 Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. AAPS J. Vriend et al.
2018 Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study. AAPS J. Suter-Dick et al.
2018 Mechanistic Investigations of Diarrhea Toxicity Induced by anti-HER2/3 Combination Therapy, Mol. Cancer Ther., Moisan et al.
2018 Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. Biomedical Microdevices. Jang et al.
2018 Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery. IEEE Trans Ultrason Ferroelectr Freq Control. Beekers et al.
2018 Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening. Sci Reports, Koo et al.
2017 96 perfusable blood vessels to study vascular permeability in vitro. Sci. Reports, van Duinen et al.
2017 Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform. BMC Cancer, Lanz et al.
2017 Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes. Nature Commun., Trietsch et al.
2017 An End-User Perspective on Organ-on-a-Chip: Assays and Usability Aspects. Curr. Op. Biom. Eng., Junaid et al.
2016 High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform. Sci. Reports, Wevers et al.
2016 Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX, Marx et al.
2016 Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening. Trends in Biotech, Wilmer et al.
2015 Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture. Lab on a Chip, Edinson et al.
2015 Microfluidic 3D cell culture: from tools to tissue models. Curr Opin Biotechnol, van Duinen et al.
2015 Morphogens and blood-brain barrier function in health and disease. Tissue Barriers, Wevers at al.
2015 On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics 9, Jang et al.
2014 Phaseguides as tunable passive microvalves for liquid routing in complex microfluidic networks. Lab on a Chip, Yildrim et al.

2013 Microfluidic titer plate for stratified 3D cell culture. Lab on a Chip, Trietsch et al.

2011 Phaseguides: a paradigm shift in microfluidic priming and emptying. Lab on a Chip, Vulto et al.

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