Understanding how glioblastoma (GBM) disrupts the blood-brain barrier (BBB) and reshapes the vascular landscape is essential to improving therapeutic strategies for this highly aggressive brain tumor. Our study presents a multi-model approach to uncover how GBM affects BBB integrity, vascular perfusion, and immune interactions, using both vascularized GBM-on-a-chip systems and patient-derived tumor spheroids.
These advanced models replicate key features of the human brain tumor microenvironment, enabling researchers to explore GBM-driven barrier disruption, non-perfusable vessel formation, and differential cytokine signaling across GBM cell lines.
Key Features of the Models
- Blood-brain barrier chip for analyzing GBM-induced barrier disruption
- Vascularized GBM model incorporating endothelial cells, pericytes, astrocytes, and GBM
- Quantification of angiogenic factor release and vascular structure changes
- Patient-derived spheroid integration on preformed vasculature
Download the poster to see how these models are enhancing our understanding of Glioblastoma
