Studying drug-induced liver injury is challenging due to the lack of predictive and scalable preclinical models. Our high-throughput liver microphysiological system replicates the human liver microenvironment, integrating hepatocytes, vascular networks, and immune components for accurate detection of small molecule and AAV-mediated hepatotoxicity.
This innovative model captures toxicity, inflammation, and gene therapy responses, making it a powerful tool for liver safety assessment and drug development. In this poster, explore how this model is advancing liver toxicity screening and gene therapy evaluation.
Key Features of the Model
- 3D liver tissue with hepatocytes, liver endothelial, stellate, and Kupffer-like cells
- Perfusable vascular networks for compound and AAV delivery via vasculature
- High-throughput compatibility with automation for efficient screening
- Predictive toxicology readouts, including albumin secretion, cytokine release, and margin of safety (MOS)
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