• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

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EN

A High-Throughput Human BBB-on-a-Chip Model for Neurological Drug Discovery of Anti-Inflammatory and Barrier Restoring Agents

The blood-brain barrier (BBB) is essential for maintaining a stable environment for the central nervous system (CNS). However, BBB dysfunction, inflammation, and immune cell infiltration contribute to neurological diseases such as multiple sclerosis, stroke, and neurodegenerative disorders. Our innovative 3D human BBB-on-a-Chip model provides a high-throughput, physiologically relevant platform for studying neuroinflammation and drug permeability.

Key Features of the Model

  • 3D perfusable BBB model – Mimics human vascular physiology
  • High-throughput screening – Supports 40 BBBs-on-chips in parallel
  • Gravity-driven microfluidic system – Enables continuous flow without pumps
  • Compatible with automated systems – Integrates with pipetting robots for high-throughput studies
  • Models inflammatory conditions – Captures barrier disruption, endothelial activation, and immune cell migration

 

 

 

Download the poster to discover how this technology accelerates CNS drug research.

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