Annually, snakebites affect up to 2.7 million people, resulting in between 81,000 and 138,000 deaths. The severe impact of these bites is often due to the hemotoxic effects of snake venoms, which disrupt blood vessels and damage endothelial cells. A deep understanding of these venom effects is essential for developing effective treatments. This poster highlights research using advanced organ-on-a-chip technology to study human blood vessel responses to various snake venoms.
Here, we introduce an assay using an automated 3D blood vessel model – the OrganoReady® Blood Vessel HUVEC – that mimics human endothelial tubules to study the hemorrhagic effects of snake venoms in real-time. This model incorporates critical physiological factors such as tubular morphology, ECM interactions, and perfusion.
These insights are vital for researchers and educators in toxicology and pharmacology, offering fresh perspectives on how venoms interact with vascular systems. This poster elaborates on the methodologies and findings, enhancing our understanding of endothelial toxicity mechanisms. This resource is invaluable for those investigating the rapid and potent effects of snake venoms.
Download the poster here
