Inflammatory airway diseases can significantly impair breathing due to airway remodeling and the excessive production of mucus. Typically, human bronchial epithelial cells are grown on culture inserts to study these changes, but such models fall short in mimicking the tubular architecture of the human bronchus, essential for reflecting the true complexity of these conditions.
To overcome these limitations, we developed a Bronchus-on-a-Chip (BoC) platform. This novel model recapitulates the physiological structure of the bronchus, enabling more accurate investigations of airway remodeling by allowing direct air and compound interactions.
This BoC platform enhances our comprehension of the underlying mechanisms of respiratory diseases and is pivotal in the development of specific treatments. It also acts as a significant educational tool for those studying respiratory medicine, showcasing the application of innovative microfluidic technology in medical research. Download the poster to gain insights into the platform.
Download the poster here
