Teasing apart the intricate biological mechanisms of the liver is essential to develop novel therapies for unsolved liver pathologies. However, most systems aiming to mimic liver tissue and disease do not capture human relevance, failing to accommodate multi-cellular types. Therefore, there is an urgent need for complex and scalable 3D in vitro models to recapitulate the physiological relevance and complexity of the human liver.
In this poster, we present our comprehensive liver model that is biologically representative of the organ’s composition, function and structure. Multiple cell types were utilized, including hepatocytes, liver endothelial cells, stellate cells and immune cells. Here, you will also learn about how steatosis and fibrosis phenotypes were successfully induced, making the model an unprecedented and robust tool to study cellular organization, mechanisms, and interactions in both healthy and diseased states of the liver. Compatible with automation and high-throughput screening, the MIMETAS liver model has the capacity to pave the way for substantial progress in novel therapies against infectious diseases and cancer
Download the poster here
