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EN

Poster: Sorafenib and Lenvatinib Induce Vascular Responses in Patient Derived HCC On-Chip Models


Poster Development of a 3D microphysiological placenta barrier in vitro model as a tool for drug transport studies Hepatocellular carcinoma (HCC) is the most common primary liver cancer accounting for approximately 90% of cases and is strongly associated with chronic liver diseases such as cirrhosis. A biologically relevant, predictive, and user-friendly HCC model is required to expedite research and develop novel therapies.

In this poster, we present the development of a screenable vascularized HCC model in the OrganoPlate® Graft using patient-derived material. This perfusable microvascular network is responsive to standard of care drugs and allows for phenotypic assessment of the vasculature organization. Here, we accomplished high-throughput screening of 30 treatment conditions, including Sorafenib and Lenvatinib, and performed vascular bed- and cytokine analysis.


Download the poster here

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