The growing utilization of medication during pregnancy over the years has raised concerns about the potential impact of pharmaceutical drugs on the developing fetus, highlighting a pressing public health issue. The lack of comprehensive safety data can be attributed to the inadequate resemblance of conventional in vivo and in vitro models to the human placenta, further exacerbating uncertainties surrounding this matter. A better and more predicting model is therefore needed.
In this poster, we present a 3D microphysiological placenta in vitro model to study drug delivery and to execute risk assessment using the OrganoPlate® 3-lane 40. By using PhaseGuide ™ technology, this platform allows for the cultivation of cells in a membrane-free manner, where they are exposed to a patterned extracellular matrix (ECM) gel. The placental barrier on-a-chip presents a promising solution for screening drug-induced toxicity, offering valuable insights for assessing the risks associated with medication use during pregnancy.
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