Perfusable Vascular Networks
Using OrganoPlate UniFlow technology, MIMETAS scientists developed stable, self-organized vascular networks for studying perfusion, immune responses, and therapeutic effects over extended periods. This intuitive system is ideal for modeling complex tissue systems and disease processes.
Key features:
- Supports intricate microvascular architecture for detailed biological studies.
- Ensures long-term morphological stability of vascular structures.
- Enables immune cell perfusion for immuno-oncology and disease research.
- Scalable, open-well format simplifies use and supports automation.
- Compatible with high-throughput workflows for broader applications.
Optimized culture conditions support a stable, perfusable vascular bed for at least 3 weeks.
Airway-on-a-Chip for Respiratory Research
MIMETAS’ Airway-on-a-Chip (AoC) model integrates unidirectional flow and perfusable microvascular networks to replicate the structural and functional complexity of human respiratory airways. This innovative model drives progress in studying respiratory diseases and fibrosis.
Key Features:
- Unidirectional, gravity-driven flow mimics airway fluid dynamics.
- 3D architecture includes differentiated bronchial epithelium and microvascular networks.
- Maintains long-term stability under Air-Liquid Interface (ALI) conditions for up to three weeks.
- Enables studies on chronic conditions like pulmonary fibrosis.
- Compatible with high-throughput applications for scaling research efforts.
Applications:
- Examines ECM remodeling and fibrotic changes induced by fibrosis-related compounds.
- Evaluates vascular and inflammatory responses for therapeutic testing.
Physiologicaly-relevant brochial tissue architecture with proper epithelium differentiation and organization.
Microvascularized Liver Model for Liver Disease and Drug Research
Leveraging OrganoPlate UF technology, MIMETAS developed a microvascularized liver model that accurately mimics human liver tissue, enabling advanced research into liver function, disease, and drug efficacy.
Key Features:
- 3D perfusable liver culture with organ-specific vascular beds formed by primary hepatocytes and non-parenchymal cells.
- Immune competence enabled through integration of Kupffer cells for inflammatory studies.
- Organ-specific functionality, including albumin production and functional vascularization.
- Long-term stability and reproducibility for studying chronic liver conditions.
Applications:
- Drug metabolism and toxicity testing, including hepatotoxicity and vascular toxicity.
- Investigation of immune-mediated injury and inflammatory triggers.
- Modeling chronic liver diseases such as fibrosis, steatosis, and NAFLD.
Immune-competent microvascularized liver. Video shows perfusion of T-cells through a vascularized bed.
