• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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Immunology Drug Discovery

Advancing Immunology Drug Discovery with 3D Tissue Models


The Need for Predictive Models

Developing effective immunology therapies is challenging, with less than 20% of investigational drugs successfully reaching the market. Traditional models, such as animal studies and 2D cell cultures, often fail to accurately replicate human immune responses, leading to high clinical trial failure rates, increased costs, and prolonged development timelines.

MIMETAS addresses these challenges by offering advanced 3D human tissue models that closely mimic human immune system interactions. These innovative platforms bridge the gap between preclinical research and clinical success, enabling researchers to better understand disease mechanisms and evaluate therapies with enhanced precision.

MIMETAS Immunology Services: Bridging the Translational Gap

MIMETAS provides adaptable organ models, including the gut, lung, liver, nervous system, and kidney, to support complex drug discovery research. By incorporating key elements like epithelial barriers, immune cells, and vasculature, these models allow researchers to study immune responses in a physiologically-relevant environment.


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Immunology Applications of 3D Tissue Models

Human Gut Models for Inflammatory Bowel Disease (IBD) Research

Inflammatory Bowel Disease (IBD) is driven by immune dysregulation, affecting millions worldwide. Its complexity—spanning epithelial barrier dysfunction, immune cell infiltration, and microbiome changes—demands advanced gut models.

MIMETAS’ 3D human gut models combine colon organoids, fibroblasts, and macrophages, providing a physiologically relevant platform to study immune responses, epithelial integrity, and drug efficacy. Researchers can investigate macrophage behavior, inflammatory pathways, and test therapies like JAK inhibitors in a controlled, dynamic environment.

Schematics of a 3D human colon organoid model that captures the complexity of the colon. Phase contrast imaging and immunofluorescent stainings of the model.

Watch our IBD Roundtable Discussion

Immune-Competent 3D Human Kidney Model for CKD Research

Immune-driven inflammation plays a central role in Chronic Kidney Disease (CKD), where complement activation attracts immune cells like monocytes and T cells, worsening kidney damage.

MIMETAS’ 3D human kidney model, featuring perfused proximal tubules and blood vessels, allows in-depth studies of complement activation, immune cell migration, and kidney inflammation. This platform supports the evaluation of therapies aimed at reducing renal inflammation and slowing disease progression.

Establishment of the tri-culture kidneymodel in the OrganoPlate platform comprising RPTECs, HUVECs, and primary monocytes culturedagainst a collagen I ECM gel.

Read the Publication

Vascular Inflammation and Immune Cell Extravasation

MIMETAS’ 3D vascular barrier models replicate immune-endothelial interactions, enabling researchers to study T-cell migration, endothelial integrity, and inflammation under physiologically relevant conditions. The vascular system directs immune cells to inflammation sites, with cytokines like TNFα activating adhesion molecules (e.g., ICAM) to facilitate immune cell attachment and migration. While vital for immune defense, prolonged recruitment can cause chronic inflammation and tissue damage.

By integrating cytokine stimulation and chemoattractants, MIMETAS’ models offer insights into immune responses and help evaluate therapies that modulate immune cell behavior and reduce inflammation.

The OrganoPlate platform with T cells (yellow) extravasation from an endothelial vessel (red) towards a chemoattractant (green). Confocal images of transendothelial T cell extravasation (green).

Watch our Vascular Inflammation Webinar

Want to explore these applications further? Download our latest whitepaper to uncover:

  • The critical need for predictive 3D models in immunology drug discovery.
  • Applications of MIMETAS’ organ-on-a-chip technology in IBD, CKD, and vascular inflammation.
  • Real-world data showcasing improved predictive accuracy and decision-making.
  • The value of partnering with MIMETAS to accelerate the development of innovative immunology therapies.


 

Download the Whitepaper

Strategic Partnership on IBD and HBV

On July 11, 2024, MIMETAS announced an Investigational New Drug (IND) filing by argenx, supported by data from MIMETAS. This preclinical collaboration focused on investigating the effects of a novel candidate in a human in vitro disease assay in MIMETAS’ OrganoPlate® platform. Its results contributed to an IND application by argenx, representing an important milestone for both companies.

Read the press release

Advancing Drug Discovery with MIMETAS

Are you interested in exploring potential partnership or service opportunities or learning more about our ongoing projects? Please contact us.


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