Customers speak: Yeoheung Yun
What does the OrganoPlate® help you do?
The OrganoPlate helps us to recapitulate the milieu of certain functional activities, mechanics, and physiological/pathological responses of the central nervous system, which will ultimately 1) allow us to screen and generate data on the toxicity of various compounds, such as Organophosphates (chemical weapon agents), or 2) facilitate analysis of higher order functional deficits relevant to complex nervous system disorders.
Since the OrganoPlate is a high-throughput and high-content platform with real-time imaging capability, it helps us construct 3D brain tissue and provides ample information for compound screening and disease modeling.
How did the OrganoPlate® transform the work you do?
The OrganoPlate allows us to develop 3D brain tissue constructs that can recapitulate in vivo brain physiology and pathology, which will aid in establishing new knowledge, screening compounds, modeling diseases, and eventually, narrowing the gap between in vitro and in vivo modeling.
Was it difficult adjusting to using the OrganoPlate®?
At the initial stage, we had difficulty injecting the cell-gel matrix into the gel lane of the OrganoPlate. However, after practicing a couple of times, we are quite comfortable with the technique and can easily construct 3D neuronal tissue.
We are now using it for different applications.
What is the biggest strength advantage of the OrganoPlate for your application?
We were interested in a platform that allowed us to create a membrane-free microfluidic-based multi-cell type brain tissue construct of the neurovascular system for in vitro brain modeling.
The OrganoPlate has significant advantages over animal models in that neurovascular interaction can be decoupled in detail in real-time, under controlled and consistent conditions.